The purpose of this study is to prepare fast dissolving tablets of Metoclopramide hydrochloride by direct compression. In the present research study, Sodium Starch Glycolate, Ac-di-sol and crosspovidone was taken as a super disintegrants. Here the Metoclopramide hydrochloride (anti-emetic) is taken as the model drug for the study and direct compression as a method for preparation of the Fast Dissolving Tablet. The comparison was done for different super disintegrants concentration and it was found that Ac- di-Sol was the best super disintegrants, and disintegrates the tablet from 15 to 22 sec. F3 batch was the best formulation and shown all the parameters like hardness, friability and disintegrating time within limit. F3 batch shown good onset of action (71.38% release of drug in 5min) and good release (98.87%) by 30 min as compared to other formulation.
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